Who opened Pandora's box?

The narrative surrounding Pandora's box is a well-known aspect of Greek mythology. In the myth, Pandora is the first woman created by the gods, specifically by Hephaestus on the orders of Zeus. She was given a box (or jar, in some versions of the story) as a gift, with instructions not to open it. However, Pandora's curiosity led her to open the box, unleashing all the evils of the world, such as disease, despair, and hardship, while leaving only hope contained within it.

This story illustrates themes of curiosity and the consequences of disobedience, elevating Pandora as central to the myth. Her action of opening the box is pivotal, as it signifies the release of troubles into the world that would affect humankind. This makes Pandora the rightful person associated with the act of opening the box.

The other figures mentioned, such as Hera, Athena, and Medusa, do not play a role in the story of Pandora’s box and are associated with different myths and narratives in Greek mythology, which is why they are not the correct answer.